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Sleep Apnea in Acute Stroke Study Launched in Germany
Sleep apnea is a known risk factor for stroke and is very common in acute stroke. The University Hospital of Munster, Germany, has begun recruitment for an NIH-registered clinical study with DVA to determine how to best diagnose and manage sleep apnea in acute stroke. NHSi is proud to be affiliated with this world class leadership in acute stroke.
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NHSi Presents Eight Papers on DVA at the European Meeting of Neurosonology and Cerebrovascular Hemodynamics
Padua, Italy - NHSi submitted 8 abstracts for the major international trade meeting in Neurosonology and all 8 were accepted for oral presentation. The topics included Sleep Apnea, Dementia, Hydrocephalus, Carotid Artery Elasticity, Altitude Sickness, Automated Data Analysis, and Predictive Modeling using DVA. The presenters were Kevin Crutchfield, MD and B. Robert Mozayeni, MD.
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DVA in Hydrocephalus Study is set to Launch at the Cleveland Clinic
After a series of outpatient clinical cases demonstrated that DVA has the potential to predict who with hydrocephalus would respond favorably to shunt treatment, NHSi decided to sponsor an independent study to confirm this in a neurocritical care inpatient setting. Mark Luciano, MD, of the Cleveland Clinic will be the principal investigator of this study to be launched in October 2005.
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Asymptomatic Reference Study Launched
The DVA Asymptomatic Reference Study has been approved by the Wake Forest IRB and will begin in October to recruit subjects from the Wake Forest University Medical Center Employee Health Program. The data collected from this study will form the nucleus of an ever-expanding data set that will make possible increasingly detailed definition of the vascular status of vital organs in specific populations across all Doppler instrument platforms.
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NHSi Recruits Director of Research Operations
Paul M. Lea IV, MS, PhD joins us from the Dept. of Neuroscience, Georgetown University where he served as a faculty member and laboratory manager after completing his postdoctoral training. Dr. Lea received his doctorate in Physiology from the Uniformed Services University of the Health Sciences, a M.S. in Biology from Villanova University, a B.S. in Biology from Cabrini College and an A.A. from Valley Forge Military College. He has 13 years experience in scientific based research and over 15 years experience in the effective use of sound management and leadership principles in a variety of environments with diverse groups.
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DVA in Altitude Sickness Paper In Press
NHSi is pleased to announce that its study elucidating the mechanism underlying altitude sickness has been accepted for publication and is "in press". Details to follow after the paper has been published.
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Dementia Study at Univ North Texas Completed
The University of North Texas has completed Phase II of its study of Dementia using DVA. The second phase of this study established that initial DVA patterns not only correlate with mental status score but also correlate with changes in mental status score and mortality at 2 years. These findings have been presented at 2 international meetings; further, these findings demonstrate that DVA can greatly improve the design of clinical trials by reducing vascular disease heterogeneity in recruited subjects.
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Sickle Cell Disease DVA Pilot Study Completed
Investigators at Wake Forest University-have completed a study of Stroke in Sickle Cell Disease in which they used DVA to demonstrate hemodynamic improvement with treatment in children who had sustained a stroke. They recently presented this work at a national meeting. Other leading investigators in Sickle Cell Disease are interested to use DVA to study legacy data from major trials of Doppler ultrasound in Sickle Cell Disease.
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Effect of CPAP in Sleep Apnea Studied using DVA
Wake Forest has recently begun to recruit subjects for a study using DVA to determine objectively, the response to therapy for sleep apnea.
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Physiology Lab Develops Model for Study of Drug Effects Using DVA
The Uniformed Services University of the Health Sciences, Bethesda, MD, has developed a model for the exploration with DVA of drug mechanisms, effects and toxicity. A pharmaceutical company has asked NHSi for a proposal to provide access to this laboratory for their preclinical drug development program. The investigators are excited by the high potential of htis new model to generate grants for their institution and NHSi expects significant revenue in 2005 from pharmaceutical company research using this model.
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NHSi Nominated for the Wall Street Journal Technology Innovation Awards
NHSi's DVA Platform develpoment partner, Optimal Solutions Inc., has nominated NHSi for the Wall Street Journal Technology Innovation Awards.
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Wake Forest Announces first DVA Course
This Fall, Professor Charles Tegeler will offer the first Wake Forest Neurosonology course on DVA in Winston Salem, NC. For more information click here
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DVA Web Platform Released
In June 2005, NHSi placed into use its web-based DVA Platform on which DVA Technical Reports are prepared. This web-based platform standardizes and automates data analysis. Developed in Microsoft .NET / Web Services, is in use servicing clients. This platform allows for servicing of clients globally, with global reading centers and cross-platform standardization.
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NHSi Automates DVA Spectral Analysis
NHSi, together with its technology partners, has enabled comprehensive automation of Doppler spectral analysis. This makes DVA an objective, automatic, and robust process for clinical use and multicenter, cross-platform clinical trials. This feature will be enabled in the next relese of NHSi's DVA Platform.
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Major Manufacturers DVA-Enable TCD Instruments
The major manufacturers of transcranial Doppler ultrasound instruments are working closely with NHSi to DVA-enable their systems. One manufacturer has nearly completed the integration process. NHSi anticipates that these instruments will become commercially available in the Fall of 2005.
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DVA Reading Center Established at Wake Forest University
Professor Charles Tegeler of Wake Forest University School of Medicine has started the Wake Forest Reading Center for Dynamic Vascular Analysis. The DVA Reading Center at Wake Forest will provide technical reviews and consultations to physicians worldwide.
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Multiple Patents Issued
NHSi was awarded over the period from 2003 to 2004, five US patents. In late 2004, the US Patent Office allowed another patent. This brings the total to 6 US patents for NHSi. NHSi has a comprehensive global intellectual property protection strategy, covering Europe and a number of other countries with potentially important DVA markets or of otehr strategic value throughout the world.
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DVA Trademarks Filed In Europe
NHSi has filed for 11 trademarks in Europe as part of a comprehensive global strategy for intellectual property.
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NHSi Launches Distance Learning Initiative
NHSi has launched a distance learning / e-learning initiative that uses state-of-the art information technology to optimize adoption of its DVA technology. One early instance of this initiative is seen in the current clincal DVA reports, that are prepared and delivered electronically and contain hyperlinks to modular educational online content. This approach allows the user (physician or patient) to learn only what is necessary to comprehend the findings and the recommendations as they read the DVA report. NHSi is currently evaluating potential partners in this distance learning initiative.
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Wake Forest to Lead CME Content Development for NHSi Distance Learning Initiative
Professor Charles Tegeler of Wake Forest University, will take the lead in developing continuing medical education (CME) content to support the improvement of quality in disease management pathways using the latest in DVA-informed algorithms. Developed in tandem with traditional courses held at Wake Forest, this CME content will be deployed in modular, electronic format to make integration into health care systems as efficient as possible.
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NHSi Partners with Stylus LLC to Develop Multimedia Presentations
Stylus LLC, www.stylusllc.com, has partnered with NHSi to develop animation-supported presentations to communicate more clearly and effectively, DVA technology to all audiences. An example of this can be seen on the NHSi home page www.newhealthsciences.com.
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Physician Focus Group Formed to Guide DVA Product Development for Outpatient Use
NHSi has formed a focus group of physician users of DVA to inform the development of its Clinical Report and to map out the adoption pathway for DVA in outpatient clinical medicine. This group meets monthly.
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